Prof. Dr. Andreas Parzefall

Lebenslauf

1997-2003 Studium der Tiermedizin (LMU)
2004 Approbation
2004-2008 Doktorarbeit am Institut für Tierpathologie (LMU) und der Division of Nephrology, University of Michigan, Ann Arbor, USA
2013 Fachtierarzt für Pathologie
20016 Habilitation, PD
2007-2017 Wissenschaftlicher Mitarbeiter am Institut für Tierpathologie, LMU München
2018-2021 Wissenschaftler am Helmholtz Zentrum München
ab 2022 Ordinarius des Lehrstuhls für Pathololgie, Institut für Tierpathologie, Zentrum für Klinische Tiermedizin Ludwig-Maximilians-Universität München

Publikationen

Prof. Parzefall publiziert unter seinem Geburtsnamen „Blutke“
ORCID https://orcid.org/0000-0001-7824-268

A pictural guide to postmortem examination of elephants.
Falkenau A, Kolb N, Rieger A, Lutzmann I, Erber K, Kaufhold C, Eddicks L, Rosati M, Fiedler S, Gager A, Michelakaki E, Dell'Era E, Lorenzen T, Zöllner M, Brühschwein A, Meyer-Lindenberg A, Heckmann J, Roller M, Reese L, Lang B, Menzinger M, Richter N, Fitz R, Pfaudler L, Lendl C, Steinmetz HW, Gohl C, Majzoub-Altweck M, Matiasek K, Blutke A. PLoS One. 2026 Feb 9;21(2):e0338783. doi: 10.1371/journal.pone.0338783. eCollection 2026. PMID: 41662433 .

Reduced Muscle Force in Dystrophic DMDΔ52 Pigs Is Incompletely Restored by Systemic Transcript Reframing (DMDΔ51-52).
Blasi M, Hristov H, Stöckl JB, Kraetzl M, Fiedler S, Kemter E, Kurome M, Kessler B, Cambra JM, Zakhartchenko V, Walter MC, Kupatt C, Klymiuk N, Fröhlich T, Blutke A, Stirm M, Jaudas F, Wolf E. J Cachexia Sarcopenia Muscle. 2025;16(5):e70084. doi: 10.1002/jcsm.70084. PMID: 41030228

Protocol for in vivo assessment of glucose control and insulin secretion and sensitivity in the pig.
Eckstein Y, Kessler B, Hinrichs A, Novak I, von Thaden A, Lorenzen T, Rathkolb B, Scholz A, Blutke A, Koopmans SJ, de Angelis MH, Christoffersen BØ, Wolf E, Renner S. STAR Protoc. 2025 Jun 20;6(2):103774. doi: 10.1016/j.xpro.2025.103774. Epub 2025 Apr 16. PMID: 40249709

The canine vibrissal system as a highly innervated and functional sensory organ.
Döring D, Müller HE, Franzmeier S, Matiasek K, Blutke A, Reese S. Sci Rep. 2025 Mar 17;15(1):9212. doi: 10.1038/s41598-025-91629-1. PMID: 40097476

Refining pain management in mice by comparing multimodal analgesia and NSAID monotherapy for neurosurgical procedures.
Munk A, Philippi V, Buchecker V, Bankstahl M, Glasenapp A, Blutke A, Michelakaki E, Talbot SR, Huwyler J, Jirkof P, Kopaczka M, Merhof D, Palme R, Potschka H. Sci Rep. 2024 Aug 12;14(1):18691. doi: 10.1038/s41598-024-69075-2. PMID: 39134625

Decreased β-cell volume and insulin secretion but preserved glucose tolerance in a growth hormone insensitive pig model.
Laane L, Renner S, Kemter E, Stirm M, Rathkolb B, Blutke A, Bidlingmaier M, de Angelis MH, Wolf E, Hinrichs A. Pituitary. 2024 Oct;27(5):567-576. doi: 10.1007/s11102-024-01424-w. Epub 2024 Jul 3. PMID: 38960990

Multi-omics analysis of diabetic pig lungs reveals molecular derangements underlying pulmonary complications of diabetes mellitus.
Shashikadze B, Flenkenthaler F, Kemter E, Franzmeier S, Stöckl JB, Haid M, Riols F, Rothe M, Pichl L, Renner S, Blutke A, Wolf E, Fröhlich T. Dis Model Mech. 2024 Jul 1;17(7):dmm050650. doi: 10.1242/dmm.050650. Epub 2024 Jul 23. PMID: 38900131

Newly Designed Poxviral Promoters to Improve Immunogenicity and Efficacy of MVA-NP Candidate Vaccines against Lethal Influenza Virus Infection in Mice.
Langenmayer MC, Luelf-Averhoff AT, Marr L, Jany S, Freudenstein A, Adam-Neumair S, Tscherne A, Fux R, Rojas JJ, Blutke A, Sutter G, Volz A. Pathogens. 2023 Jun 23;12(7):867. doi: 10.3390/pathogens12070867. PMID: 37513714

Standardized tissue sampling guidelines for histopathological and molecular analyses of rainbow trout (Oncorhynchus mykiss) in ecotoxicological studies.
Fiedler S, Schrader H, Theobalt N, Hofmann I, Geiger T, Arndt D, Wanke R, Schwaiger J, Blutke A. PLoS One. 2023 Jul 13;18(7):e0288542. doi: 10.1371/journal.pone.0288542. eCollection 2023. PMID: 37440561

Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52.
Stirm M, Shashikadze B, Blutke A, Kemter E, Lange A, Stöckl JB, Jaudas F, Laane L, Kurome M, Keßler B, Zakhartchenko V, Bähr A, Klymiuk N, Nagashima H, Walter MC, Wurst W, Kupatt C, Fröhlich T, Wolf E. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2301250120. doi: 10.1073/pnas.2301250120. Epub 2023 Jul 10. PMID: 37428903

Trapping all ERBB ligands decreases pancreatic lesions in a murine model of pancreatic ductal adenocarcinoma.
Hedegger K, Blutke A, Hommel T, Auer KE, Nataraj NB, Lindzen M, Yarden Y, Dahlhoff M. Mol Oncol. 2023 Nov;17(11):2415-2431. doi: 10.1002/1878-0261.13473. Epub 2023 Jul 14. PMID: 37341059

Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland: Lessons from a translational pig model.
Shashikadze B, Franzmeier S, Hofmann I, Kraetzl M, Flenkenthaler F, Blutke A, Fröhlich T, Wolf E, Hinrichs A. J Neuroendocrinol. 2024 Jul;36(7):e13277. doi: 10.1111/jne.13277. Epub 2023 May 9. PMID: 37160285

Demodex carolliae in a colony of Seba's short-tailed bats (Carollia perspicillata): clinical, pathological and parasitological findings.
Rieger A, Just FT, Michelakaki E, Eddicks L, Gager AM, Schöl H, Gohl C, Steinmetz HW, Blutke AF, Denk D. J Comp Pathol. 2023 May;203:5-12. doi: 10.1016/j.jcpa.2023.03.185. Epub 2023 Apr 28. PMID: 37119605

Hepatitis B Virus Targets Lipid Transport Pathways to Infect Hepatocytes.
Esser K, Cheng X, Wettengel JM, Lucifora J, Hansen-Palmus L, Austen K, Roca Suarez AA, Heintz S, Testoni B, Nebioglu F, Pham MT, Yang S, Zernecke A, Wohlleber D, Ringelhan M, Broxtermann M, Hartmann D, Hüser N, Mergner J, Pichlmair A, Thasler WE, Heikenwalder M, Gasteiger G, Blutke A, Walch A, Knolle PA, Bartenschlager R, Protzer U. Cell Mol Gastroenterol Hepatol. 2023;16(2):201-221. doi: 10.1016/j.jcmgh.2023.03.011. Epub 2023 Apr 11. PMID: 37054914

Immobility-associated thromboprotection is conserved across mammalian species from bear to human.
Thienel M, Müller-Reif JB, Zhang Z, Ehreiser V, Huth J, Shchurovska K, Kilani B, Schweizer L, Geyer PE, Zwiebel M, Novotny J, Lüsebrink E, Little G, Orban M, Nicolai L, El Nemr S, Titova A, Spannagl M, Kindberg J, Evans AL, Mach O, Vogel M, Tiedt S, Ormanns S, Kessler B, Dueck A, Friebe A, Jørgensen PG, Majzoub-Altweck M, Blutke A, Polzin A, Stark K, Kääb S, Maier D, Gibbins JM, Limper U, Frobert O, Mann M, Massberg S, Petzold T. Science. 2023 Apr 14;380(6641):178-187. doi: 10.1126/science.abo5044. Epub 2023 Apr 13. PMID: 37053338

ARBM101 (Methanobactin SB2) Drains Excess Liver Copper via Biliary Excretion in Wilson's Disease Rats.
Einer C, Munk DE, Park E, Akdogan B, Nagel J, Lichtmannegger J, Eberhagen C, Rieder T, Vendelbo MH, Michalke B, Wimmer R, Blutke A, Feuchtinger A, Dershwitz P, DiSpirito AM, Islam T, Castro RE, Min BK, Kim T, Choi S, Kim D, Jung C, Lee H, Park D, Im W, Eun SY, Cho YH, Semrau JD, Rodrigues CMP, Hohenester S, Damgaard Sandahl T, DiSpirito AA, Zischka H. Gastroenterology. 2023 Jul;165(1):187-200.e7. doi: 10.1053/j.gastro.2023.03.216. Epub 2023 Mar 24. PMID: 36966941

Preclinical Assessment of Tissue Effects by Gastrointestinal Endoscope Tip Temperature.
Jäger L, Morales-Orcajo E, Gager A, Bader A, Dillinger A, Blutke A. Curr Ther Res Clin Exp. 2023 Jan 26;98:100693. doi: 10.1016/j.curtheres.2023.100693. eCollection 2023. PMID: 36820232

Detection of Diclofenac-Induced Alterations in Rainbow Trout (Oncorhynchus mykiss) Using Quantitative Stereological Methods.
Birzle C, Schrader H, Blutke A, Ferling H, Scholz-Göppel K, Wanke R, Schwaiger J. Environ Toxicol Chem. 2023 Apr;42(4):859-872. doi: 10.1002/etc.5573. Epub 2023 Mar 10. PMID: 36705425

Intracranial Subdural Fluid Accumulation Associated with a Choroid Plexus Carcinoma in a Dog.
Schneider N, Blutke A, Matiasek K, Parzefall B. Vet Sci. 2022 Dec 30;10(1):24. doi: 10.3390/vetsci10010024. PMID: 36669025

RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling.
Kuhn LB, Valentin S, Stojanovic K, Strobl DC, Babushku T, Wang Y, Rambold U, Scheffler L, Grath S, John-Robbert D, Blum H, Feuchtinger A, Blutke A, Weih F, Kitamura D, Rad R, Strobl LJ, Zimber-Strobl U. Front Immunol. 2022 Aug 30;13:913275. doi: 10.3389/fimmu.2022.913275. eCollection 2022. PMID: 36110848

Pig models for Duchenne muscular dystrophy - from disease mechanisms to validation of new diagnostic and therapeutic concepts.
Stirm M, Fonteyne LM, Shashikadze B, Stöckl JB, Kurome M, Keßler B, Zakhartchenko V, Kemter E, Blum H, Arnold GJ, Matiasek K, Wanke R, Wurst W, Nagashima H, Knieling F, Walter MC, Kupatt C, Fröhlich T, Klymiuk N, Blutke A, Wolf E. Neuromuscul Disord. 2022 Jul;32(7):543-556. doi: 10.1016/j.nmd.2022.04.005. Epub 2022 Apr 25. PMID: 35659494

Epaxial muscle atrophy is more evident in large dogs with intervertebral disc disease than in dogs with ischaemic myelopathy.
Boström AF, Parzefall B, Blutke A, Davies ES. Res Vet Sci. 2022 Sep;146:60-69. doi: 10.1016/j.rvsc.2022.03.011. Epub 2022 Mar 17. PMID: 35339099

Recovery after inadvertent intramedullary microchip implantation at C1-C2 in a kitten.
Schneider N, Blutke A, Parzefall B. JFMS Open Rep. 2022 Mar 16;8(1):20551169221081398. doi: 10.1177/20551169221081398. eCollection 2022 Jan-Jun. PMID: 35321496

Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes.
Grotz S, Schäfer J, Wunderlich KA, Ellederova Z, Auch H, Bähr A, Runa-Vochozkova P, Fadl J, Arnold V, Ardan T, Veith M, Santamaria G, Dhom G, Hitzl W, Kessler B, Eckardt C, Klein J, Brymova A, Linnert J, Kurome M, Zakharchenko V, Fischer A, Blutke A, Döring A, Suchankova S, Popelar J, Rodríguez-Bocanegra E, Dlugaiczyk J, Straka H, May-Simera H, Wang W, Laugwitz KL, Vandenberghe LH, Wolf E, Nagel-Wolfrum K, Peters T, Motlik J, Fischer MD, Wolfrum U, Klymiuk N. EMBO Mol Med. 2022 Apr 7;14(4):e14817. doi: 10.15252/emmm.202114817. Epub 2022 Mar 7. PMID: 35254721

A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis.
Loft A, Schmidt SF, Caratti G, Stifel U, Havelund J, Sekar R, Kwon Y, Sulaj A, Chow KK, Alfaro AJ, Schwarzmayr T, Rittig N, Svart M, Tsokanos FF, Maida A, Blutke A, Feuchtinger A, Møller N, Blüher M, Nawroth P, Szendrödi J, Færgeman NJ, Zeigerer A, Tuckermann J, Herzig S. Cell Metab. 2022 Mar 1;34(3):473-486.e9. doi: 10.1016/j.cmet.2022.01.004. Epub 2022 Feb 3. PMID: 35120589

Differential Effects of Insulin-Deficient Diabetes Mellitus on Visceral vs. Subcutaneous Adipose Tissue-Multi-omics Insights From the Munich MIDY Pig Model.
Flenkenthaler F, Ländström E, Shashikadze B, Backman M, Blutke A, Philippou-Massier J, Renner S, Hrabe de Angelis M, Wanke R, Blum H, Arnold GJ, Wolf E, Fröhlich T. Front Med (Lausanne). 2021 Nov 23;8:751277. doi: 10.3389/fmed.2021.751277. eCollection 2021. PMID: 34888323

A scalable, clinically severe pig model for Duchenne muscular dystrophy.
Stirm M, Fonteyne LM, Shashikadze B, Lindner M, Chirivi M, Lange A, Kaufhold C, Mayer C, Medugorac I, Kessler B, Kurome M, Zakhartchenko V, Hinrichs A, Kemter E, Krause S, Wanke R, Arnold GJ, Wess G, Nagashima H, Hrabĕ de Angelis M, Flenkenthaler F, Kobelke LA, Bearzi C, Rizzi R, Bähr A, Reese S, Matiasek K, Walter MC, Kupatt C, Ziegler S, Bartenstein P, Fröhlich T, Klymiuk N, Blutke A, Wolf E. Dis Model Mech. 2021 Dec 1;14(12):dmm049285. doi: 10.1242/dmm.049285. Epub 2021 Dec 16. PMID: 34796900

Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice.
Huang S, Blutke A, Feuchtinger A, Klemm U, Zachariah Tom R, Hofmann SM, Stiel AC, Ntziachristos V. EMBO Mol Med. 2021 Sep 7;13(9):e13490. doi: 10.15252/emmm.202013490. Epub 2021 Aug 19. PMID: 34411447

A new method for physical disector analyses of numbers and mean volumes of immunohistochemically labeled cells in paraffin sections.
Hofmann I, Kemter E, Fiedler S, Theobalt N, Fonteyne L, Wolf E, Wanke R, Blutke A. J Neurosci Methods. 2021 Sep 1;361:109272. doi: 10.1016/j.jneumeth.2021.109272. Epub 2021 Jul 1. PMID: 34216707

Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Georgiadi A, Lopez-Salazar V, Merahbi RE, Karikari RA, Ma X, Mourão A, Klepac K, Bühler L, Alfaro AJ, Kaczmarek I, Linford A, Bosma M, Shilkova O, Ritvos O, Nakamura N, Hirose S, Lassi M, Teperino R, Machado J, Scheideler M, Dietrich A, Geerlof A, Feuchtinger A, Blutke A, Fischer K, Müller TD, Kessler K, Schöneberg T, Thor D, Hornemann S, Kruse M, Nawroth P, Pivovarova-Ramich O, Pfeiffer AFH, Sattler M, Blüher M, Herzig S. Nat Commun. 2021 May 20;12(1):2999. doi: 10.1038/s41467-021-22579-1. PMID: 34016966

Croconaine-based nanoparticles enable efficient optoacoustic imaging of murine brain tumors.
Liu N, Gujrati V, Malekzadeh-Najafabadi J, Werner JPF, Klemm U, Tang L, Chen Z, Prakash J, Huang Y, Stiel A, Mettenleiter G, Aichler M, Blutke A, Walch A, Kleigrewe K, Razansky D, Sattler M, Ntziachristos V. Photoacoustics. 2021 Mar 23;22:100263. doi: 10.1016/j.pacs.2021.100263. eCollection 2021 Jun. PMID: 33948433

Facile Synthesis of a Croconaine-Based Nanoformulation for Optoacoustic Imaging and Photothermal Therapy.
Liu N, O'Connor P, Gujrati V, Gorpas D, Glasl S, Blutke A, Walch A, Kleigrewe K, Sattler M, Plettenburg O, Ntziachristos V. Adv Healthc Mater. 2021 May;10(9):e2002115. doi: 10.1002/adhm.202002115. Epub 2021 Mar 18. PMID: 33738974

Unbiased analysis of obesity related, fat depot specific changes of adipocyte volumes and numbers using light sheet fluorescence microscopy.
Theobalt N, Hofmann I, Fiedler S, Renner S, Dhom G, Feuchtinger A, Walch A, Hrabĕ de Angelis M, Wolf E, Wanke R, Blutke A. PLoS One. 2021 Mar 16;16(3):e0248594. doi: 10.1371/journal.pone.0248594. eCollection 2021. PMID: 33725017

Transcriptomic landscape of radiation-induced murine thyroid proliferative lesions.
Stauffer E, Weber P, Heider T, Dalke C, Blutke A, Walch A, Burgstaller G, Brix N, Lauber K, Zitzelsberger H, Unger K, Selmansberger M. Endocr Relat Cancer. 2021 Mar;28(3):213-224. doi: 10.1530/ERC-21-0019. PMID: 33608487

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.
Zhang Q, Delessa CT, Augustin R, Bakhti M, Colldén G, Drucker DJ, Feuchtinger A, Caceres CG, Grandl G, Harger A, Herzig S, Hofmann S, Holleman CL, Jastroch M, Keipert S, Kleinert M, Knerr PJ, Kulaj K, Legutko B, Lickert H, Liu X, Luippold G, Lutter D, Malogajski E, Medina MT, Mowery SA, Blutke A, Perez-Tilve D, Salinno C, Sehrer L, DiMarchi RD, Tschöp MH, Stemmer K, Finan B, Wolfrum C, Müller TD. Cell Metab. 2021 Apr 6;33(4):833-844.e5. doi: 10.1016/j.cmet.2021.01.015. Epub 2021 Feb 10. PMID: 33571454

A practical guide to unbiased quantitative morphological analyses of the gills of rainbow trout (Oncorhynchus mykiss) in ecotoxicological studies.
Fiedler S, Wünnemann H, Hofmann I, Theobalt N, Feuchtinger A, Walch A, Schwaiger J, Wanke R, Blutke A. PLoS One. 2020 Dec 9;15(12):e0243462. doi: 10.1371/journal.pone.0243462. eCollection 2020. PMID: 33296424

Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies.
Hinrichs A, Riedel EO, Klymiuk N, Blutke A, Kemter E, Längin M, Dahlhoff M, Keßler B, Kurome M, Zakhartchenko V, Jemiller EM, Ayares D, Bidlingmaier M, Flenkenthaler F, Hrabĕ de Angelis M, Arnold GJ, Reichart B, Fröhlich T, Wolf E. Xenotransplantation. 2021 Mar;28(2):e12664. doi: 10.1111/xen.12664. Epub 2020 Nov 25. PMID: 33241624

A decade of experience with genetically tailored pig models for diabetes and metabolic research.
Zettler S, Renner S, Kemter E, Hinrichs A, Klymiuk N, Backman M, Riedel EO, Mueller C, Streckel E, Braun-Reichhart C, Martins AS, Kurome M, Keßler B, Zakhartchenko V, Flenkenthaler F, Arnold GJ, Fröhlich T, Blum H, Blutke A, Wanke R, Wolf E. Anim Reprod. 2020 Aug 26;17(3):e20200064. doi: 10.1590/1984-3143-AR2020-0064. PMID: 33029223

Chronic Occupational Exposure to Ionizing Radiation Induces Alterations in the Structure and Metabolism of the Heart: A Proteomic Analysis of Human Formalin-Fixed Paraffin-Embedded (FFPE) Cardiac Tissue.
Azimzadeh O, Azizova T, Merl-Pham J, Blutke A, Moseeva M, Zubkova O, Anastasov N, Feuchtinger A, Hauck SM, Atkinson MJ, Tapio S. Int J Mol Sci. 2020 Sep 17;21(18):6832. doi: 10.3390/ijms21186832. PMID: 32957660

Progressive Proteome Changes in the Myocardium of a Pig Model for Duchenne Muscular Dystrophy.
Tamiyakul H, Kemter E, Kösters M, Ebner S, Blutke A, Klymiuk N, Flenkenthaler F, Wolf E, Arnold GJ, Fröhlich T. iScience. 2020 Sep 1;23(9):101516. doi: 10.1016/j.isci.2020.101516. eCollection 2020 Sep 25. PMID: 32927262

Light sheet fluorescence microscopy guided MALDI-imaging mass spectrometry of cleared tissue samples.
Blutke A, Sun N, Xu Z, Buck A, Harrison L, Schriever SC, Pfluger PT, Wiles D, Kunzke T, Huber K, Schlegel J, Aichler M, Feuchtinger A, Matiasek K, Hauck SM, Walch A. Sci Rep. 2020 Sep 2;10(1):14461. doi: 10.1038/s41598-020-71465-1. PMID: 32879402

Normal Tissue Response of Combined Temporal and Spatial Fractionation in Proton Minibeam Radiation Therapy.
Sammer M, Dombrowsky AC, Schauer J, Oleksenko K, Bicher S, Schwarz B, Rudigkeit S, Matejka N, Reindl J, Bartzsch S, Blutke A, Feuchtinger A, Combs SE, Dollinger G, Schmid TE. Int J Radiat Oncol Biol Phys. 2021 Jan 1;109(1):76-83. doi: 10.1016/j.ijrobp.2020.08.027. Epub 2020 Aug 14. PMID: 32805301

Unraveling ERBB network dynamics upon betacellulin signaling in pancreatic ductal adenocarcinoma in mice.
Hedegger K, Algül H, Lesina M, Blutke A, Schmid RM, Schneider MR, Dahlhoff M. Mol Oncol. 2020 Aug;14(8):1653-1669. doi: 10.1002/1878-0261.12699. Epub 2020 May 18. PMID: 32335999

Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model.
Riedel EO, Hinrichs A, Kemter E, Dahlhoff M, Backman M, Rathkolb B, Prehn C, Adamski J, Renner S, Blutke A, de Angelis MH, Bidlingmaier M, Schopohl J, Arnold GJ, Fröhlich T, Wolf E. Mol Metab. 2020 Jun;36:100978. doi: 10.1016/j.molmet.2020.100978. Epub 2020 Mar 18. PMID: 32277923

Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn's disease recurrence.
Khaloian S, Rath E, Hammoudi N, Gleisinger E, Blutke A, Giesbertz P, Berger E, Metwaly A, Waldschmitt N, Allez M, Haller D. Gut. 2020 Nov;69(11):1939-1951. doi: 10.1136/gutjnl-2019-319514. Epub 2020 Feb 28. PMID: 32111634

Porcine models for studying complications and organ crosstalk in diabetes mellitus.
Renner S, Blutke A, Clauss S, Deeg CA, Kemter E, Merkus D, Wanke R, Wolf E. Cell Tissue Res. 2020 May;380(2):341-378. doi: 10.1007/s00441-019-03158-9. Epub 2020 Jan 13. PMID: 31932949

Linkage between growth retardation and pituitary cell morphology in a dystrophin-deficient pig model of Duchenne muscular dystrophy.
Hofmann I, Kemter E, Theobalt N, Fiedler S, Bidlingmaier M, Hinrichs A, Aichler M, Burkhardt K, Klymiuk N, Wolf E, Wanke R, Blutke A. Growth Horm IGF Res. 2020 Apr;51:6-16. doi: 10.1016/j.ghir.2019.12.006. Epub 2019 Dec 31. PMID: 31926372

Proliferative Kidney Disease and Proliferative Darkening Syndrome are Linked with Brown Trout (Salmo trutta fario) Mortalities in the Pre-Alpine Isar River.
Arndt D, Fux R, Blutke A, Schwaiger J, El-Matbouli M, Sutter G, Langenmayer MC. Pathogens. 2019 Oct 6;8(4):177. doi: 10.3390/pathogens8040177. PMID: 31590460

Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring.
Renner S, Martins AS, Streckel E, Braun-Reichhart C, Backman M, Prehn C, Klymiuk N, Bähr A, Blutke A, Landbrecht-Schessl C, Wünsch A, Kessler B, Kurome M, Hinrichs A, Koopmans SJ, Krebs S, Kemter E, Rathkolb B, Nagashima H, Blum H, Ritzmann M, Wanke R, Aigner B, Adamski J, Hrabě de Angelis M, Wolf E. Dis Model Mech. 2019 Aug 12;12(8):dmm039156. doi: 10.1242/dmm.039156. PMID: 31308048

Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus.
Backman M, Flenkenthaler F, Blutke A, Dahlhoff M, Ländström E, Renner S, Philippou-Massier J, Krebs S, Rathkolb B, Prehn C, Grzybek M, Coskun Ü, Rothe M, Adamski J, de Angelis MH, Wanke R, Fröhlich T, Arnold GJ, Blum H, Wolf E. Mol Metab. 2019 Aug;26:30-44. doi: 10.1016/j.molmet.2019.05.011. Epub 2019 Jun 4. PMID: 31221621

Acute Skin Damage and Late Radiation-Induced Fibrosis and Inflammation in Murine Ears after High-Dose Irradiation.
Dombrowsky AC, Schauer J, Sammer M, Blutke A, Walsh DWM, Schwarz B, Bartzsch S, Feuchtinger A, Reindl J, Combs SE, Dollinger G, Schmid TE. Cancers (Basel). 2019 May 25;11(5):727. doi: 10.3390/cancers11050727. PMID: 31130616

Strain specific maturation of Dendritic cells and production of IL-1β controls CD40-driven colitis.
Ogrinc Wagner A, Friedrich V, Barthels C, Marconi P, Blutke A, Brombacher F, Brocker T. PLoS One. 2019 Jan 17;14(1):e0210998. doi: 10.1371/journal.pone.0210998. eCollection 2019. PMID: 30653608

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.
Renner S, Blutke A, Dobenecker B, Dhom G, Müller TD, Finan B, Clemmensen C, Bernau M, Novak I, Rathkolb B, Senf S, Zöls S, Roth M, Götz A, Hofmann SM, Hrabĕ de Angelis M, Wanke R, Kienzle E, Scholz AM, DiMarchi R, Ritzmann M, Tschöp MH, Wolf E. Mol Metab. 2018 Oct;16:180-190. doi: 10.1016/j.molmet.2018.06.015. Epub 2018 Jun 28. PMID: 30017782

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.
Hinrichs A, Kessler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, de Angelis MH, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M, Wolf E. Mol Metab. 2018 May;11:113-128. doi: 10.1016/j.molmet.2018.03.006. Epub 2018 Mar 15. PMID: 29678421

Sampling Strategies and Processing of Biobank Tissue Samples from Porcine Biomedical Models.
Blutke A, Wanke R. J Vis Exp. 2018 Mar 6;(133):57276. doi: 10.3791/57276. PMID: 29578524

Practicable methods for histological section thickness measurement in quantitative stereological analyses.
Matenaers C, Popper B, Rieger A, Wanke R, Blutke A. PLoS One. 2018 Feb 14;13(2):e0192879. doi: 10.1371/journal.pone.0192879. eCollection 2018. PMID: 29444158

The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.
Blutke A, Renner S, Flenkenthaler F, Backman M, Haesner S, Kemter E, Ländström E, Braun-Reichhart C, Albl B, Streckel E, Rathkolb B, Prehn C, Palladini A, Grzybek M, Krebs S, Bauersachs S, Bähr A, Brühschwein A, Deeg CA, De Monte E, Dmochewitz M, Eberle C, Emrich D, Fux R, Groth F, Gumbert S, Heitmann A, Hinrichs A, Keßler B, Kurome M, Leipig-Rudolph M, Matiasek K, Öztürk H, Otzdorff C, Reichenbach M, Reichenbach HD, Rieger A, Rieseberg B, Rosati M, Saucedo MN, Schleicher A, Schneider MR, Simmet K, Steinmetz J, Übel N, Zehetmaier P, Jung A, Adamski J, Coskun Ü, Hrabě de Angelis M, Simmet C, Ritzmann M, Meyer-Lindenberg A, Blum H, Arnold GJ, Fröhlich T, Wanke R, Wolf E. Mol Metab. 2017 Jun 13;6(8):931-940. doi: 10.1016/j.molmet.2017.06.004. eCollection 2017 Aug. PMID: 28752056

Retinopathy with central oedema in an INS C94Y transgenic pig model of long-term diabetes.
Kleinwort KJH, Amann B, Hauck SM, Hirmer S, Blutke A, Renner S, Uhl PB, Lutterberg K, Sekundo W, Wolf E, Deeg CA. Diabetologia. 2017 Aug;60(8):1541-1549. doi: 10.1007/s00125-017-4290-7. Epub 2017 May 8. PMID: 28480495

CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis.
Barthels C, Ogrinc A, Steyer V, Meier S, Simon F, Wimmer M, Blutke A, Straub T, Zimber-Strobl U, Lutgens E, Marconi P, Ohnmacht C, Garzetti D, Stecher B, Brocker T. Nat Commun. 2017 Mar 9;8:14715. doi: 10.1038/ncomms14715. PMID: 28276457

Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice.
Gimpfl M, Rozman J, Dahlhoff M, Kübeck R, Blutke A, Rathkolb B, Klingenspor M, Hrabě de Angelis M, Öner-Sieben S, Seibt A, Roscher AA, Wolf E, Ensenauer R. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1605-1614. doi: 10.1016/j.bbadis.2017.02.021. Epub 2017 Feb 21. PMID: 28235645

[Detection of Salmonella Choleraesuis var. Kunzendorf in a fattening pig with septicaemic salmonellosis. A case report].
Eddicks M, Hausleitner R, Eddicks L, Blutke A, Straubinger RK, Wolf G, Szabo I, Heizer C, Hermanns W, Ritzmann M. Tierarztl Prax Ausg G Grosstiere Nutztiere. 2016 Dec 5;44(6):381-387. doi: 10.15653/TPG-160300. Epub 2016 Nov 3. PMID: 27808343 German.

Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy.
Fröhlich T, Kemter E, Flenkenthaler F, Klymiuk N, Otte KA, Blutke A, Krause S, Walter MC, Wanke R, Wolf E, Arnold GJ. Sci Rep. 2016 Sep 16;6:33362. doi: 10.1038/srep33362. PMID: 27634466

Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle.
Rieger A, Kemter E, Kumar S, Popper B, Aigner B, Wolf E, Wanke R, Blutke A. PLoS One. 2016 Jul 15;11(7):e0158977. doi: 10.1371/journal.pone.0158977. eCollection 2016. PMID: 27420727

A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer.
Kinzel L, Ernst A, Orth M, Albrecht V, Hennel R, Brix N, Frey B, Gaipl US, Zuchtriegel G, Reichel CA, Blutke A, Schilling D, Multhoff G, Li M, Niyazi M, Friedl AA, Winssinger N, Belka C, Lauber K. Oncotarget. 2016 Jul 12;7(28):43199-43219. doi: 10.18632/oncotarget.9774. PMID: 27259245

Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research.
Renner S, Dobenecker B, Blutke A, Zöls S, Wanke R, Ritzmann M, Wolf E. Theriogenology. 2016 Jul 1;86(1):406-21. doi: 10.1016/j.theriogenology.2016.04.055. Epub 2016 Apr 21. PMID: 27180329

Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation.
Kleinert E, Langenmayer MC, Reichart B, Kindermann J, Griemert B, Blutke A, Troidl K, Mayr T, Grantzow T, Noyan F, Abicht JM, Fischer S, Preissner KT, Wanke R, Deindl E, Guethoff S. J Am Heart Assoc. 2016 Apr 27;5(5):e003429. doi: 10.1161/JAHA.116.003429. PMID: 27121849

Growth hormone (GH)-transgenic insulin-like growth factor 1 (IGF1)-deficient mice allow dissociation of excess GH and IGF1 effects on glomerular and tubular growth.
Blutke A, Schneider MR, Wolf E, Wanke R. Physiol Rep. 2016 Mar;4(5):e12709. doi: 10.14814/phy2.12709. PMID: 26997624

Tissue Sampling Guides for Porcine Biomedical Models.
Albl B, Haesner S, Braun-Reichhart C, Streckel E, Renner S, Seeliger F, Wolf E, Wanke R, Blutke A. Toxicol Pathol. 2016 Apr;44(3):414-20. doi: 10.1177/0192623316631023. Epub 2016 Feb 16. PMID: 26883152

Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies.
Klymiuk N, Seeliger F, Bohlooly-Y M, Blutke A, Rudmann DG, Wolf E. Toxicol Pathol. 2016 Apr;44(3):346-57. doi: 10.1177/0192623315609688. Epub 2015 Oct 27. PMID: 26511847

Incretin actions and consequences of incretin-based therapies: lessons from complementary animal models.
Renner S, Blutke A, Streckel E, Wanke R, Wolf E. J Pathol. 2016 Jan;238(2):345-58. doi: 10.1002/path.4655. Epub 2015 Nov 30. PMID: 26455904

Effects of the glucagon-like peptide-1 receptor agonist liraglutide in juvenile transgenic pigs modeling a pre-diabetic condition.
Streckel E, Braun-Reichhart C, Herbach N, Dahlhoff M, Kessler B, Blutke A, Bähr A, Übel N, Eddicks M, Ritzmann M, Krebs S, Göke B, Blum H, Wanke R, Wolf E, Renner S. J Transl Med. 2015 Feb 25;13:73. doi: 10.1186/s12967-015-0431-2. PMID: 25890210

Acaricide treatment prevents adrenocortical hyperplasia as a long-term stress reaction to psoroptic mange in cattle.
Blutke A, Börjes P, Herbach N, Pfister K, Hamel D, Rehbein S, Wanke R. Vet Parasitol. 2015 Jan 15;207(1-2):125-33. doi: 10.1016/j.vetpar.2014.10.013. Epub 2014 Oct 24. PMID: 25468014

Prevalence and characterization of small tympanic bone spicules and drumstick-like hyperostotic tympanic bone spicules in the middle ear cavity of dogs.
Parzefall B, Rieger A, Volk HA, Maierl J, Brühschwein A, Blutke A. Vet Radiol Ultrasound. 2015 Jan-Feb;56(1):25-32. doi: 10.1111/vru.12197. Epub 2014 Aug 19. PMID: 25138894

Location-specific expression of chemokines, TNF-α and S100 proteins in a teat explant model.
Lind M, Sipka AS, Schuberth HJ, Blutke A, Wanke R, Sauter-Louis C, Duda KA, Holst O, Rainard P, Germon P, Zerbe H, Petzl W. Innate Immun. 2015 Apr;21(3):322-31. doi: 10.1177/1753425914539820. Epub 2014 Aug 17. PMID: 25134520

Genetic dissection of IGF1-dependent and -independent effects of permanent GH excess on postnatal growth and organ pathology of mice.
Blutke A, Schneider MR, Renner-Müller I, Herbach N, Wanke R, Wolf E. Mol Cell Endocrinol. 2014 Aug 25;394(1-2):88-98. doi: 10.1016/j.mce.2014.07.002. Epub 2014 Jul 10. PMID: 25017732

[Torsion of a liver cyst in a calf].
Wieland M, Blutke A, Mann S. Tierarztl Prax Ausg G Grosstiere Nutztiere. 2014;42(2):106-11. PMID: 24737156 German.

Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring.
Dahlhoff M, Pfister S, Blutke A, Rozman J, Klingenspor M, Deutsch MJ, Rathkolb B, Fink B, Gimpfl M, Hrabě de Angelis M, Roscher AA, Wolf E, Ensenauer R. Biochim Biophys Acta. 2014 Feb;1842(2):304-17. doi: 10.1016/j.bbadis.2013.11.021. Epub 2013 Nov 23. PMID: 24275555

Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs.
Wuensch A, Baehr A, Bongoni AK, Kemter E, Blutke A, Baars W, Haertle S, Zakhartchenko V, Kurome M, Kessler B, Faber C, Abicht JM, Reichart B, Wanke R, Schwinzer R, Nagashima H, Rieben R, Ayares D, Wolf E, Klymiuk N. Transplantation. 2014 Jan 27;97(2):138-47. doi: 10.1097/TP.0b013e3182a95cbc. PMID: 24150517

Polycystic kidney disease in a European roe deer (Capreolus capreolus).
Blutke A, März K, Matenaers C, Oswald K, Hermanns W, Wanke R. J Zoo Wildl Med. 2013 Jun;44(2):487-90. doi: 10.1638/2012-0131R.1. PMID: 23805573

Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle.
Klymiuk N, Blutke A, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, Kemter E, Nagashima H, Schoser B, Herbach N, Blum H, Wanke R, Aartsma-Rus A, Thirion C, Lochmüller H, Walter MC, Wolf E. Hum Mol Genet. 2013 Nov 1;22(21):4368-82. doi: 10.1093/hmg/ddt287. Epub 2013 Jun 19. PMID: 23784375

Permanent neonatal diabetes in INS(C94Y) transgenic pigs.
Renner S, Braun-Reichhart C, Blutke A, Herbach N, Emrich D, Streckel E, Wünsch A, Kessler B, Kurome M, Bähr A, Klymiuk N, Krebs S, Puk O, Nagashima H, Graw J, Blum H, Wanke R, Wolf E. Diabetes. 2013 May;62(5):1505-11. doi: 10.2337/db12-1065. Epub 2012 Dec 28. PMID: 23274907

Opening a treasure chest: glomerular proteome analyses of formalin-fixed paraffin-embedded kidney tissue in the investigation of diabetic nephropathy.
Blutke A. Nephrol Dial Transplant. 2012 May;27(5):1695-8. doi: 10.1093/ndt/gfs082. PMID: 22547746 No abstract available.

A case of congenital unilateral hip dysplasia in a newborn calf.
Mann S, Blutke A, Brühschwein A, Feist M. Schweiz Arch Tierheilkd. 2011 Oct;153(10):457-61. doi: 10.1024/0036-7281/a000248. PMID: 21971673

In vivo evidence for epidermal growth factor receptor (EGFR)-mediated release of prolactin from the pituitary gland.
Dahlhoff M, Blutke A, Wanke R, Wolf E, Schneider MR. J Biol Chem. 2011 Nov 11;286(45):39297-306. doi: 10.1074/jbc.M111.243493. Epub 2011 Sep 13. PMID: 21914800

Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria.
Blutke A, Block C, Berendt F, Herbach N, Kemter E, Amann K, Fröhlich T, Arnold GJ, Wanke R. Proteomics Clin Appl. 2011 Jun;5(5-6):375-81. doi: 10.1002/prca.201000103. Epub 2011 Apr 29. PMID: 21538912

Naturally-occurring canine herpesvirus-1 infection of the vestibular labyrinth and ganglion of dogs.
Parzefall B, Fischer A, Blutke A, Schmahl W, Matiasek K. Vet J. 2011 Jul;189(1):100-2. doi: 10.1016/j.tvjl.2010.06.014. Epub 2010 Aug 8. PMID: 20696601

Cystic echinococcosis due to Echinococcus equinus in a horse from southern Germany.
Blutke A, Hamel D, Hüttner M, Gehlen H, Romig T, Pfister K, Hermanns W. J Vet Diagn Invest. 2010 May;22(3):458-62. doi: 10.1177/104063871002200323. PMID: 20453228

Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2).
van Bürck L, Blutke A, Kautz S, Rathkolb B, Klaften M, Wagner S, Kemter E, Hrabé de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N. Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E512-23. doi: 10.1152/ajpendo.00465.2009. Epub 2009 Dec 1. PMID: 19952346

Evidence of feline herpesvirus-1 DNA in the vestibular ganglion of domestic cats.
Parzefall B, Schmahl W, Fischer A, Blutke A, Truyen U, Matiasek K. Vet J. 2010 Jun;184(3):371-2. doi: 10.1016/j.tvjl.2009.03.030. Epub 2009 Apr 25. PMID: 19394881

Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis.
Herbach N, Schairer I, Blutke A, Kautz S, Siebert A, Göke B, Wolf E, Wanke R. Am J Physiol Renal Physiol. 2009 Apr;296(4):F819-29. doi: 10.1152/ajprenal.90665.2008. Epub 2009 Feb 11. PMID: 19211686

A rapid approach to ultrastructural evaluation and DNA analysis of the vestibular labyrinth and ganglion in dogs and cats.
Parzefall B, Schmahl W, Blutke A, Baiker K, Matiasek K. J Neurosci Methods. 2009 Feb 15;177(1):217-24. doi: 10.1016/j.jneumeth.2008.10.003. Epub 2008 Oct 17. PMID: 18984005

Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight.
Moerth C, Schneider MR, Renner-Mueller I, Blutke A, Elmlinger MW, Erben RG, Camacho-Hübner C, Hoeflich A, Wolf E. Endocrinology. 2007 Jan;148(1):441-51. doi: 10.1210/en.2006-0385. Epub 2006 Sep 28. PMID: 17008389CV Prof. Dr. Andreas Falko Parzefall